SHAFA – RAFOXAN a halogenated salicylanilide anthelmintic against the trematode spp. (Flukes) , some nematodes (round worms) and larval stage of sheep nasal bot fly.

It is extensively bound to plasma proteins and has a long terminal half – life , so it acquires a prolonged persistence in the plasma which leads to the effect against the immature flukes.

As proton ionophore , transporting cations across cell membranes , it acts by uncoupling oxidative phosphorylation within parasitic mitochondria resulting into its death.

INDICATIONS:

 For the treatment and control of the following parasitic infestations:

Flukes:

*Liver flukes(mature and immature stages): Fasciola hepatica , F.gigantica.

*Other flukes: Dicrocoelium dendriticum.

* Blood sucking nematode: Haemonchus contortus.

*Files larvae: Sheep nasal bot (Oestrus ovis) , Lucilia.